Coupling of phagocytic nadph oxidase activity and mitochondrial superoxide production

HIGHLIGHTS

  • who: Sergey I. Dikalov from the University, Russia have published the paper: Coupling of phagocytic NADPH oxidase activity and mitochondrial superoxide production, in the Journal: (JOURNAL)
  • what: The utility of simultaneous use of 15 N- and 14 N-labeled nitroxides in cellular/tissue distribution studies have been shown previously, however this approach have never been used for hydroxylamine spin probes and superoxide detection in different cellular compartments.
  • how: The authors have used 15 N-and deuterium-enriched spin probe 15 N-CAT1H for high sensitivity and site-specific detection of extracellular superoxide. The . . .

     

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