Coupling the cardiac voltage-gated sodium channel to channelrhodopsin-2 generates novel optical switches for action potential studies

HIGHLIGHTS

  • who: Christian vom Dahl and colleagues from the Institute of Physiology II, University Hospital Jena, Friedrich Schiller University, Jena, Germany have published the Article: Coupling the Cardiac Voltage-Gated Sodium Channel to Channelrhodopsin-2 Generates Novel Optical Switches for Action Potential Studies, in the Journal: Membranes 2022, 907 of /2022/
  • what: Using one of these novel optical switches, the authors show in Xenopus laevis oocytes the specific effect of two functionally distinct delayed rectifier K+ channels (Kv 1.2 3 of 20 and hERG), and the Nav 1.5 deletion mutant u2206KPQ on AP repolarization . . .

     

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