Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of sars-cov-2 main protease

HIGHLIGHTS

• who: Daniel W. Kneller from the Ridge National Laboratory, Oak Ridge, TN, USAUniversity of have published the paper: Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The study provides unique information on the structural and thermodynamic details of the hybrid reversible covalent inhibitors binding to SARS-CoV-2 Mpro and demonstrates that these compounds are viable for further design of potent antivirals against SARS-CoV-2.
• how: This result is probably caused by substituting the bulky hydrophobic P4/P5 groups . . .
  

   

  

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