Covalent tcr-peptide-mhc interactions induce t cell activation and redirect t cell fate in the thymus

HIGHLIGHTS

• who: Christopher Szeto from the Mice B Rag1-/- mice (Rag1tm Bal, ) were purchased from Bioservices Kew, Walter and Eliza Hall Institute of Medical Research (Melbourne, Australia). , mice, and mice carrying Tcratm Mom, mtm Jae, H Aatm Blt, Zap70mrd, Zap70mrt, BCL2-tg (Tg(Vav-BCL2) Jad)61, Yae62β-tg, Foxp3tm Ayr (Foxp GFP)62, all on the , genetic background, were bred (intercrossed in some cases) and housed in specific-pathogen-free environments at, °C and, % humidity with a lighting cycle of , a.m. to , p.m. light (below , lux) and , p.m. to , a.m. darkness, at the . . .
  

   

  

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