HIGHLIGHTS
- who: Giorgia Benegiamo from the (UNIVERSITY) have published the paper: COX7A2L genetic variants determine cardiorespiratory fitness in mice and human, in the Journal: (JOURNAL) of 18/Oct/2021
- what: COX7A2L lead cis-eQTL affects mRNA stability To investigate the mechanism of genetic variation in COX7A2L expression in humans, the authors focused on the most significant cis-eQTL in the GTEx database (rs4181). The authors show that Cox7a2l is induced in skeletal muscle upon exercise in mice and that humans with higher expression of COX7A2L have improved metabolic and cardiorespiratory phenotypes. While the authors observe an . . .
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