HIGHLIGHTS
- who: Michelandrea De Cesare from the Milan, Italy have published the research: CpG-oligodeoxynucleotides exert remarkable antitumor activity against diffuse malignant peritoneal mesothelioma orthotopic xenografts, in the Journal: (JOURNAL)
- what: The authors assessed the efficacy of CpGODN1826 in two DMPM orthotopic xenografts (MesoII and STO), which properly recapitulate the dissemination pattern in the peritoneal cavity of human DMPM and, for this reason, represent valuable models for investigating novel therapeutics. The authors demonstrate for the first time that locally administered CpG-ODN1826, a synthetic DNA sequence recognized by TLR9 and able to induce innate/ adaptive immune_response . . .
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