Cpg site-specific methylation-modulated divergent expression of prss3 transcript variants facilitates nongenetic intratumor heterogeneity in human hepatocellular carcinoma

HIGHLIGHTS

• who: Shuye Lin from the Peking University Health Science Centre, China have published the research: CpG Site-Specific Methylation-Modulated Divergent Expression of PRSS3 Transcript Variants Facilitates Nongenetic Intratumor Heterogeneity in Human Hepatocellular Carcinoma, in the Journal: (JOURNAL)
• what: The study showed the differential expression of PRSS3 as a DEG in HCC across a large expression range that could be used to phenotypically distinguish between PRSS3Low and PRSS3High HCC cells and tissues. The study provides additional evidence supporting the hypothesis of functional hepatoheterogeneity attributed to genetic and epigenetic factors .
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