Crag: de novo characterization of cell-free dna fragmentation hotspots in plasma whole-genome sequencing

HIGHLIGHTS

• who: Xionghui Zhou from the Public datasets used in this study are listed in Additional file, : Table S During the method development process for the hotspot detection, we utilized the deeply sequenced cfDNA WGS data (BH01) from Snyder et_al , study [6]. For cfDNA WGS in liver cancer, we utilized , healthy, HCC, HBV, and , Cirrhosis samples from Jiang et_al , study [41]. For the application of cfDNA WGS in multiple other cancers, we utilized , samples from Cristiano et_al , study [2], including , healthy, breast cancer, bile duct cancer, colorectal cancer, gastric cancer, lung cancer, ovarian cancer, and , pancreatic cancer samples . . .
  

   

  

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