Cre-recombinase induces apoptosis and cell death in enterocyte organoids

HIGHLIGHTS

• who: Franziska Moll and colleagues from the Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany have published the research: Cre-Recombinase Induces Apoptosis and Cell Death in Enterocyte Organoids, in the Journal: Antioxidants 2022, 11, 1452. of /2022/
• what: The authors show that although NADPH oxidases are important for in vivo differentiation and proliferation of the intestine their expression is drastically reduced in the organoid system. The authors provide evidence that acute activation of Cre-recombinase can induce DNA damage, apoptosis and growth inhibition in intestinal organoids.
• how: The authors analyzed two models . . .
  

   

  

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