Creation of philadelphia chromosome by crispr/cas9-mediated double cleavages on bcr and abl1 genes as a model for initial event in leukemogenesis

HIGHLIGHTS

• who: Minori Tamai from the (UNIVERSITY) have published the Article: Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis, in the Journal: (JOURNAL) of 25/05/2022

SUMMARY

In most CML patients and approximately one-quarter of Ph chromosomepositive (Ph + ) ALL patients, exon 13 or 14 of the BCR gene is fused to exon 2 of the ABL1 gene, which encodes p210 BCR::ABL1 fusion_protein. In the other Ph+ ALL patients, exon 2 of the BCR gene is fused . . .

 



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