Crispr-based knockout screening identifies the loss of mief2 to enhance oxaliplatin resistance in colorectal cancer through inhibiting the mitochondrial apoptosis pathway

HIGHLIGHTS

• who: Chaozheng Xie from the Yangpu Hospital, China of Pisa, Italy have published the Article: CRISPR-based knockout screening identifies the loss of MIEF2 to enhance oxaliplatin resistance in colorectal cancer through inhibiting the mitochondrial apoptosis pathway, in the Journal: (JOURNAL)
• what: The authors used the library screening strategy described by Feng Zhang , A genomewide knockdown screening of CRC cells treated with and without OXL led to the identification of 3736 positively enriched genes and the authors determined that the deletion of MIEF2 was an important driver of OXL resistance.
• how: For this . . .
  

   

  

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