Crispr/cas9-generated mouse model with humanizing single-base substitution in the gnao1 for safety studies of rna

HIGHLIGHTS

• who: GNAO and colleagues from the Institute of Higher Nervous Activity and Neurophysiology (RAS), Russia Kyushu, Japan have published the research work: CRISPR/Cas9-generated mouse model with humanizing single-base substitution in the Gnao1 for safety studies of RNA, in the Journal: (JOURNAL)
• what: The authors report a mouse model Gnao1-GGA (Bardina et_al, 2021) with the 68-nucleotide coding fragment of the endogenous Gnao1, spanning the junction of exons 5 and 6, 100% identical to the wild-type human sequence (Supplementary Figure S3).
• how: The authors applied CRISPR/Cas9 technology to . . .
  

   

  

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