Crispr/cas9-mediated mutagenesis of sex-specific doublesex splicing variants leads to sterility in spodoptera frugiperda, a global invasive pest

HIGHLIGHTS

SUMMARY

Dsx was first found to produce male- and female-specific proteins via alternative splicing that regulate sex differentiation in Drosophila melanogaster. Although previous studies show that splicing isoforms of dsxF and dsxM dictate sex determination in multiple insects, i.e., somatic sexual differentiation of dsx is fundamentally conserved among insects, the sex determination cascade in S. frugiperda is still not fully understood. In Spodoptera litura, adult male dsx mutants showed smaller testes and an inability to mate with wildtype females. SIT is a classical genetic pest control strategy used to suppress pest populations in . . .

 



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