Crispr dna base editing strategies for treating retinitis pigmentosa caused by mutations in rhodopsin

HIGHLIGHTS

• who: Maria Kaukonen and colleagues from the Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford , DU, UK have published the article: CRISPR DNA Base Editing Strategies for Treating Retinitis Pigmentosa Caused by Mutations in Rhodopsin, in the Journal: Genes 2022, 13, 1327. of 19/04/2022
• what: The authors analyzed previously reported pathogenic variants (n = 247) for suitable PAM sites for currently available base editors utilizing the Streptococcus pyogenes Cas9 (SpCas9) Staphylococcus aureus Cas9 (SaCas9) or the KKH variant of SaCas9 (KKH-SaCas9) to assess DNA base editing as treatment option for RHO-associated . . .
  

   

  

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