Critical contributions of pre-s1 shoulder and distal trp box in dag-activated trpc6 channel by pip2 regulation

HIGHLIGHTS

• who: Masayuki X. Mori from the LaboratoryUniversity of have published the research work: Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation, in the Journal: Scientific Reports Scientific Reports
• what: Given that the dissociation_constant for P u00ad IP2 binding to T u00ad RPC6WT was previously reported to be 2 u00b5M15, the authors propose that those for u00adPIP2 binding to the pre-S1 domain/shoulder mutants (R437Q and K442Q) are greater than 10 u00b5M. The authors introduced neutralizing mutations to various selected basic residues.
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