HIGHLIGHTS
- who: Soonbum Park from the (UNIVERSITY) have published the research work: Crizotinib attenuates cancer metastasis by inhibiting TGFu03b2 signaling in non-small cell lung cancer cells, in the Journal: (JOURNAL) of 23/08/2022
- what: Molecular docking and amino_acid sequence analyses provided clues to the inhibitory mechanism of crizotinib on Tu03b2RI; the model showed that crizotinib directly binds to the kinase domain of Tu03b2RI (Supplementary Figs 8a-c, 9; see their legends for details). This study shows that crizotinib attenuates cancer metastasis by ALK/MET/RON/ROS1-independent inhibition of TGFu03b2 signaling in NSCLC cells . . .
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