Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs

HIGHLIGHTS

  • who: L. Henry Goodnough from the University College London, United Kingdom have published the research work: Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs, in the Journal: (JOURNAL)
  • what: The authors demonstrate that NSAIDs have disparate and species-specific effects on osteochondrogenic differentiation of homologous populations of murine and human fracture-derived SSCs, which are prospectively isolated and a highly purified cell population.
  • how: The authors will also have to test if the same results are obtained when a catalytically inactive COX2 variant . . .

     

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