HIGHLIGHTS
- What: This study reports the restoration of miR-623 inhibits trans-endothelial migration of brain-tropic TNBC cells, thereby suppressing BCBM . The study by Miragen Therapeutics was discontinued during Phase II (NCT03713320) due to business reasons.
- Who: . and collaborators from the The University of Tokyo, Japan have published the paper: Crosstalk between breast cancer-derived microRNAs and brain microenvironmental cells in breast cancer brain metastasis, in the Journal: (JOURNAL)
- Future: These studies suggest that miRNAs play key roles in regulating multiple stages of BCBM however further investigations into these mechanisms are necessary.
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