HIGHLIGHTS
- who: Zheng Zhou from the (UNIVERSITY) have published the paper: Crowded Cell-like Environment Accelerates the Nucleation Step of Amyloidogenic Protein Misfolding*, in the Journal: (JOURNAL) of October/30,/2009
- what: This work explores the mechanisms of the enhancing effects of macromolecular crowding on protein misfolding and addresses the physiological question why and how macromolecular crowding will affect fibril formation of proteins associated with neurodegenerative diseases. Based on the biochemical data and the recently reported results , the authors propose a valuable hypothesis relating to the tendency of natively unfolded proteins to form fibrils under crowded . . .
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