Crp deposition in human abdominal aortic aneurysm is associated with transcriptome alterations toward aneurysmal pathogenesis: insights from in situ spatial whole transcriptomic analysis

HIGHLIGHTS

• What: The authors aimed to investigate the transcriptomic changes associated with CRP deposition in AAAs to elucidate the underlying mechanisms contributing to poorer prognosis and larger aortic diameter in patients with elevated CRP levels. Both IRBs approved the use of clinical data and the collection and utilization of biological samples for research purposes, exempting the need for formal written informed consent. This study investigated the lineage-specific transcriptome of AAA tissue in relation to the degree of CRP deposition by employing GeoMx for spatially resolved whole RNA transcriptome analysis. Given that CRP deposition in the study correlates . . .
  

   

  

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