HIGHLIGHTS
- who: Lu Zhang from the State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy, Nankai University, Tianjin, China have published the research: Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2, in the Journal: (JOURNAL)
- what: The authors report the cryo-EM structures of Mycobacterium smegmatis EmbB in its "resting state" and DPA-bound "active state". The authors show that ethambutol inhibits the enzymatic activity of the EmbB2-AcpM2 complex and structurally identify the site that is most susceptible to ethambutol resistance based on isolates from clinical studies. spectrometry . . .
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