Cryo-em structure and activator screening of human tryptophan hydroxylase 2

HIGHLIGHTS

  • who: Hydroxylase et al. from the Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China, Cryo-EM Facility have published the Article: Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2, in the Journal: (JOURNAL)
  • what: The authors conducted free_energy estimation using the approach of MM/PBSA to characterize the stability of the TPH2 complex in a semiquantitative method (Thompson et_al, 2008; Cavalheiro et_al, 2017; Poli et_al, 2020).

SUMMARY

    TPH1 and TPH2, together with phenylalanine hydroxylase (PAH) and tyrosine hydroxylase (TH), form the family of pterin . . .

     

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