Cryo-em structure of an amyloid fibril formed by full-length human sod1 reveals its conformational conversion

HIGHLIGHTS

• who: Li-Qiang Wang from the College Wuhan University of Sciences, Shanghai, China have published the paper: Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• how: Together these data showed that full-length apo SOD1 forms cytotoxic mitochondrial dysfunction-inducing amyloid fibrils under reducing conditions.
• future: The authors plan to collect structural data on various SOD1 mutations including metal-binding region mutants H46R H46D G85R and D125H and wild-type-like mutants A4V D90A and G93A in . . .
  

   

  

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