Cryo-em structure of an attrwt amyloid fibril from systemic non-hereditary transthyretin amyloidosis

HIGHLIGHTS

• who: Maximilian Steinebrei from the A male patient was diagnosed with non-hereditary ATTR amyloidosis at the age of , yearsThe , exons of the transthyretin gene were sequenced from the blood of the patient to identify amyloidogenic variants and no variants were found in our patient. Heart failure worsened the next years and the patient received heart transplant , years later at an age of , years. Until heart transplantation the patient was not treated with disease-specific drugs. Stage of disease at the diagnosis was stage , which corresponds to the New York Heart Association (NYHA) Functional Classification class I . . .
  

   

  

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