Cryo-em structure of the human cst-polα/primase complex in a recruitment state

HIGHLIGHTS

• who: Sarah W. Cai from the LaboratoryRockefeller University have published the paper: Cryo-EM structure of the human CST-Polu03b1/primase complex in a recruitment state, in the Journal: (JOURNAL) of 17/Dec/2021
• what: The authors report novel structure of the human CST-Polu03b1/ fill-in machinery. The authors propose this interaction is specific to metazoans and occurs during recruitment of to the telomere prior to the start of RNA/DNA synthesis by the enzyme.
• future: The two binding modes are consistent with the cryo -EM structure in which POLA1CTD utilizes both . . .
  

   

  

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