Cryo-em structures of amyloid-β filaments with the arctic mutation (e22g) from human and mouse brains

HIGHLIGHTS

• who: Yang Yang from the Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden have published the research: Cryo-EM structures of amyloid-u03b2 filaments with the Arctic mutation (E22G) from human and mouse brains, in the Journal: (JOURNAL)
• what: The authors report the high-resolution cryo-EM structures of Au03b2 filaments from the frontal cortex of a previously described case (Au03b2PParc1) with the Arctic mutation.

SUMMARY

Dominantly inherited mutations in the amyloid precursor protein gene (APP) that cause disease are a mainstay of the amyloid cascade hypothesis of Alzheimer`s . . .

 



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