Cryo-em structures of human a2ml1 elucidate the protease-inhibitory mechanism of the a2m family

HIGHLIGHTS

• who: Nadia Sukusu Nielsen from the Aarhus University have published the research: Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 17/Dec/2021
• what: Based on the structures , the authors propose that disordered regions in A2ML1 provide a pivotal contribution to protease sequestration and the authors suggest a unified mechanism for the conformational change occurring upon proteolytic activation of A2MF proteins. The authors focus on the structure of A2ML1-CC determined at 2.9 u00c5 resolution and use the structure . . .
  

   

  

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