Cryo-em structures of human fucosidase fuca1 reveal insight into substrate recognition and catalysis

HIGHLIGHTS

• who: Zachary Armstrong from the Structural Biology Laboratory University of York, Heslington, York , DD, UK have published the research: Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis, in the Journal: (JOURNAL)
• what: This work has conclusively identified the hitherto contentious identity of the catalytic acid/base as aspartate-276 representing a shift from both the canonical glutamate acid/base residue and a previously proposed glutamate residue.
• how: As this protein is naturally glycosylated (Alhadeff et_al 1975) the authors chose to express it in eukaryotic Trichoplusa ni (that . . .
  

   

  

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