Cryoem-sampling of metastable conformations appearing in cofactor-ligand association and catalysis of glutamate dehydrogenase

HIGHLIGHTS

  • What: For the initial stage, the authors propose a hypothetical reaction pathway in the deamination reaction composed of four metastable conformations (Fig 7A).
  • Who: Taiki Wakabayashi from the DepartmentKeio University Japan have published the Article: CryoEM-sampling of metastable conformations appearing in cofactor-ligand association and catalysis of glutamate dehydrogenase, in the Journal: Scientific Reports Scientific Reports
  • How: This result was consistent with the radius of gyration value in the steady stage (42.2 ± 0.1 Å) which was slightly smaller than that of the unliganded state (43.2 ± 0.1 Å) (Supplementary Note 1 . . .

     

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