Crystal structure and functional analysis of mycobacterial erythromycin resistance methyltransferase erm38 reveals its rna-binding site

HIGHLIGHTS

  • who: Boon Chong Goh from the Boon Chong Goh1, *, Xinyu Xiang3, Julien Lescar1, , *, and Peter CDedon1, * From the Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, Singapore, Singapore have published the paper: Crystal structure and functional analysis of mycobacterial erythromycin resistance methyltransferase Erm38 reveals its RNA-binding site, in the Journal: (JOURNAL) of December/29,/2021
  • what: This model shows the RNA substrate stably bound to Erm38 by a patch of positively charged residues.

SUMMARY

    Based on structural analysis and mutagenesis, the authors identified several catalytically . . .

     

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