Crystal structure of active cdk4-cyclin d and mechanistic basis for abemaciclib efficacy

HIGHLIGHTS

• who: Severine Isabelle Gharbi from the (UNIVERSITY) have published the research: Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy, in the Journal: (JOURNAL) of 29/Nov/2022
• what: The authors determine the first x-ray crystal_structure of active CDK4 in complex with cyclin D3, in the presence of the CDK4/6 inhibitor abemaciclib. The authors show in breast cancer cells that abemaciclib stabilizes primed CDK4-cyclin D complex and displaces p21, not observed in CDK6-cyclin D models, resulting in altered sensitivity in breast cancer models with greater CDK6 expression . . .
  

   

  

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