Crystal structure of human cd47 in complex with engineered sirp.d1(n80a)

HIGHLIGHTS

• who: Jifeng Yu and collaborators from the Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China have published the research work: Crystal Structure of Human CD47 in Complex with Engineered SIRP.D1(N80A), in the Journal: Molecules 2022, 27, 5574. of /2022/
• what: The authors explore the crystal_structure of CD47/IMM01, a novel SIRPα-Fc fusion_protein.
• how: Crystal observation was carried out in two different conditions IMM01-Fab/CD47hisCSHT-B5 and IMM01-Fab/CD47his-PR-G4 . The crystal_structure results showed that CD47 and SIRPα d1 formed a 11 stoichiometry complex . . .
  

   

  

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