Crystal structure of pyrrolysyl-trna synthetase from a methanogenic archaeon iso4-g1 and its structure-based engineering for highly-productive cell-free genetic code expansion with non-canonical amino acids

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  • who: Tatsuo Yanagisawa and colleagues from the RIKEN Center for Biosystems Dynamics Research, Suehiro-Cho, Tsurumi, Yokohama, Japan have published the research work: Crystal Structure of Pyrrolysyl-tRNA Synthetase from a Methanogenic Archaeon ISO4-G1 and Its Structure-Based Engineering for Highly-Productive Cell-Free Genetic Code Expansion with Non-Canonical Amino Acids, in the Journal: (JOURNAL) of 28/05/2020
  • what: The authors determined the crystal structure of the PylRS PylRS) and compared it with those of structure-known PylRSs. The authors demonstrated that the ISO4-G1 PylRS system extensively improved the protein productivities . . .

     

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