HIGHLIGHTS
- who: Jingxu Guo from the University of, Leiden, The Netherlands have published the article: Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors report crystal_structures of BMP10:BMPRII complex in two crystal forms, and the ALK1:BMP10:BMPRII signalling complex. The authors show that although BMPRII utilises the same hydrophobic core as ActRIIA/ B and binds to BMP10 at the knuckle epitope, the longer A-loop and finger 3 loop (F3-loop) in BMPRII make unique interactions. The authors show . . .
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