HIGHLIGHTS
- who: Bum Soo Hong from the (UNIVERSITY) have published the research work: Crystal Structures of Human Pantothenate Kinases, in the Journal: (JOURNAL) of September/21,/2007
SUMMARY
PANK4 encodes a protein with sequence similarity to the other PanKs, but it lacks an essential catalytic glutamate for enzyme activity and has a long carboxyl-terminal extension of unknown function. Overall Structure Description Acetyl-CoA was a competitive inhibitor of both PanK1 and PanK3 (Fig 3, B and C), suggesting that the binding of acetyl-CoA interfered with the ATP binding by stabilizing the open . . .
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