Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates*

HIGHLIGHTS

• who: Yu-Shan Hsiao from the Yu-Shan Hsiao, Gerwald Jogl1, and Liang Tong, From the Department of Biological Sciences, Columbia University, New York, New York , Carnitine acyltransferases catalyze the reversible exchange of acyl groups between coenzyme A (CoA) and carnitineThey have important roles in many cellular processes, especially the oxidation of long-chain fatty acids in the mitochondria for energy production, and are attractive targets for drug discovery against diabetes and obesity. To help define in molecular detail the catalytic mechanism of these enzymes, we report here the high resolution crystal structure of wild-type murine . . .
  

   

  

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