HIGHLIGHTS
- who: Iain F. Davidson from the (UNIVERSITY) have published the research: CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion, in the Journal: (JOURNAL) of 16/03/2023
- what: The authors show that CTCF is sufficient to block diffusing cohesin, possibly reflecting how cohesive cohesin accumulates at TAD boundaries, and is also sufficient to block loop-extruding cohesin, reflecting how CTCF establishes TAD boundaries.
- future: At low DNA tension the authors observed events in which CTCF indeed switched the direction of cohesin`s loop-extrusion activity.
SUMMARY
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