Ctgf is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis

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• who: Lipson et_al Fibrogenesis Tissue and colleagues from the Connective tissue growth factor (CTGF, CCN2) is a member of a small family of proteins that are characterized by their highly conserved disulfide bonding pattern and having, domains with homology to other proteins [1, ]CTGF has four domains: domain , is homologous to , binding proteins, domain , is homologous to the von Willebrand factor type C repeat, domain , is homologous to the thrombospondin type , repeat and domain , contains a cysteine knot motif that is common to proteins that bind to heparan sulfate proteoglycans (HSPGs). The two, terminal domains (, and, ) are . . .
  

   

  

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