Ctla-4 silencing in dendritic cells loaded with colorectal cancer cell lysate improves autologous t cell responses in vitro

HIGHLIGHTS

• who: Farid Ghorbaninezhad from the The First Hospital of Jilin University, China have published the article: CTLA-4 silencing in dendritic cells loaded with colorectal cancer cell lysate improves autologous T cell responses in vitro, in the Journal: (JOURNAL)
• what: The main reason for this is supposed to be antigen presentation weakness, diminished tumor-specific antigen expression, activation of immunosuppressive pathways, immune checkpoint signaling pathways, and presence of immune regulatory cells . The authors demonstrated that CTLA-4 silencing in CRC cell lysate-loaded DCs enhances their stimulation and leads to boosted autologous T_cells' activation and . . .
  

   

  

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