Curcumin reduces pathological endoplasmic reticulum stress through increasing proteolysis of mutant matrilin-3

HIGHLIGHTS

• who: Ella P. Dennis and colleagues from the International Centre for Life, Biosciences Institute, Newcastle University, Newcastle upon Tyne , BZ, UK have published the Article: Curcumin Reduces Pathological Endoplasmic Reticulum Stress through Increasing Proteolysis of Mutant Matrilin-3, in the Journal: (JOURNAL)
• what: In line with a previous study, here the authors show that curcumin treatment promotes protective XBP1 splicing in V194D mutant matrilin3-expressing cells, which results in a significant upregulation of XBP1s target genes .
• how: ER Stress Caused by the Retention of Mutant Matrilin-3 without Affecting Wild-Type Cells Based . . .
  

   

  

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