Current and future therapeutic approaches of exocrine pancreatic insufficiency in children with cystic fibrosis in the era of personalized medicine

HIGHLIGHTS

SUMMARY

On a more detailed view of its role, the authors find CFTR physiologically expressed on the surface of airway epithelial_cells, having a regulatory role considering the chloride ion_channel. This mechanism depicted at the level of the airway epithelial_cell develops similarly in other epithelial_cells of exocrine glands, e_g, the pancreas. CFTR protein functions as a chloride and bicarbonate ion_channel on the apical membrane of the epithelial_cells of exocrine glands. In their study, Walkowiak et_al, demonstrated that the genotype of a CF patient is strongly linked with the probability of developing exocrine pancreatic insufficiency but not . . .

 



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