HIGHLIGHTS
- who: Wensheng Che et al. from the Verona University Hospital, Italy have published the article: Current insights in molecular characterization of non-alcoholic fatty liver disease and treatment, in the Journal: Gut microbiota
SUMMARY
Hyperglycemia and toxic lipids such as ceramides, diacylglycerol (DAG), free fatty_acid (FFA), and cholesterol in hepatocytes may result in deleterious effects (glucolipotoxicity), which may change NAFLD from simple steatosis to NASH through mechanisms including cellular death, oxidative stress, and mitochondrial disorders. Unbalanced gut microbiota exposes liver cells to an endotoxic environment by producing short-chain fatty_acids and secondary bile . . .
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