Current sequence-based models capture gene expression determinants in promoters but mostly ignore distal enhancers

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SUMMARY

    Accordingly, models which can reliably predict gene_expression directly from sequence would not only be of scientific interest but could potentially find many uses in the design of personalized diagnoses and treatments. Currently, no sequence-based model is capable of holistically accounting for all stages of gene_expression from transcription initiation to protein degradation and can thus predict the abundance of each processed protein isoform in any given cellular context. For the sake of simplicity, the authors will follow the convention in the literature and use RNA abundance and gene_expression synonymously, even if the former is . . .

     

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