Current understanding of iga antibodies in the pathogenesis of iga nephropathy

HIGHLIGHTS

  • who: IgA et al. from the Universitu00e9 de Paris, France University College Cork, Ireland have published the paper: Current understanding of IgA antibodies in the pathogenesis of IgA nephropathy, in the Journal: (JOURNAL)
  • future: Experiments revealed that this serine residue in CDR3 is required for effective binding to Gd-IgA1.

SUMMARY

    Immunoglobulin A (IgA) is the most abundant isotype of antibodies (Abs); approximately 66 mg/kg IgA Abs is generated daily from antibody-secreting cells (ASCs) that reside mainly in the mucosal lumen. As a result, serum IgA1 with decreased galactose . . .

     

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