HIGHLIGHTS
- who: Shweta S. Puntambekar from the Stark Neurosciences Research Institute, Indiana University-School have published the research work: CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimeru2019s disease, in the Journal: (JOURNAL)
- what: In this report, the authors investigate how microglial responses to Au03b2 shaped by CX3CR1 drive long term neurotoxicity in the 5xFAD model of amyloid disease. Using 5xFAD animals, the authors demonstrate that in addition to skewing the microenvironment towards the accumulation of increasingly neurotoxic Au03b2 species, the loss of CX3CR1 signaling in AD results in impaired microglial plaque engagement . . .
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