HIGHLIGHTS
- who: Marinos Kallikourdis from the Washington University in StLouis, United States have published the paper: CXCL12 Mediates Aberrant Costimulation of B Lymphocytes in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Immunodeficiency, in the Journal: (JOURNAL)
- what: In the work , the authors identify, in WHIM patients as well as in WHIM knock-in mice, that B cells are characterized by increased propensity for apoptosis and by a spontaneous expression of activation markers, in the absence of exogenous experimental stimulation. The results the authors report above suggest that aberrant costimulation in WHIM B cells may impair their survival and thus . . .
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