Cxcl16 signals via gi, phosphatidylinositol 3-kinase, akt, iκb kinase, and nuclear factor-κb and induces cell-cell adhesion and aortic smooth muscle cell proliferation*

HIGHLIGHTS

• who: Bysani Chandrasekar from the (UNIVERSITY) have published the research work: CXCL16 Signals via Gi, Phosphatidylinositol 3-Kinase, Akt, IκB Kinase, and Nuclear Factor-κB and Induces Cell-Cell Adhesion and Aortic Smooth Muscle Cell Proliferation*, in the Journal: (JOURNAL) of October/23,/2003
• what: The authors demonstrate for the first time that human ASMC express CXCR6 and that treatment with CXCL16 activates NF-␬B via heterotrimeric G proteins/PI3K/PDK-1/Akt/IKK/I␬B. Most importantly, treatment of ASMC with CXCL16 increases cell-cell adhesion and cellular proliferation. Using pharmacological inhibitors and . . .
  

   

  

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