HIGHLIGHTS
- who: Chao Yang from the Department have published the paper: CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors characterize the pro-inflammatory impact of CXCL4, and mechanisms by which CXCL4 cooperates with TLR8, in primary human monocytes, which correspond to cells that migrate into inflammatory sites and are highly relevant for disease pathogenesis.
- how: Although initially puzzling this result is in accord with the attenuation of the IFN response that was observed by RNAseq at . . .
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