Cyb5r3 in type ii alveolar epithelial_cells protects against lung fibrosis by suppressing tgf-β1 signaling

HIGHLIGHTS

• who: Judith Brands et al. from the DivisionUniversity of Pennsylvania, USA have published the Article: CYB5R3 in type II alveolar epithelial_cells protects against lung fibrosis by suppressing TGF-u03b21 signaling, in the Journal: (JOURNAL)
• what: The authors show that expression of membrane-bound cytochrome B5 reductase 3 (CYB5R3) an enzyme critical for maintaining cellular redox homeostasis and soluble guanylate cyclase (sGC) heme iron redox state is diminished in IPF AECIIs. The authors demonstrate that sGC agonists (BAY 41-8543 and BAY 54-6544) are effective in reducing the pulmonary fibrotic outcomes of in vivo deficiency . . .
  

   

  

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