Cyclohexyl ketone inhibitors of pin1 dock in a trans- diaxial cyclohexane conformation

HIGHLIGHTS

• who: Guoyan G. Xu and colleagues from the Department of Chemistry, Virginia Tech, Blacksburg, Virginia, United States of America have published the Article: Cyclohexyl Ketone Inhibitors of Pin1 Dock in a Trans- Diaxial Cyclohexane Conformation, in the Journal: PLOS ONE | www.plosone.org of September/19,/2012
• what: Three stereoisomeric ketone analogues of Pin1 substrates were synthesized, modeled, and assayed as Pin1 inhibitors.
• how: These results argue against the proposed nucleophilicaddition mechanism for Pin1 . containing inhibitors were more potent than the L-Thr in work by Zhang et al both diastereomers 1 and . . .
  

   

  

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